Reginald Cini a product of the Valletta F.C. Youth Nursery, born in the capital City on October 22, 1970.  Cini made his debut with the senior Squad in season 1987/88. In season 1988/89 Cini suffered only nine goals during the Premier League while in season 1989/90 he only suffered six goals.

At an early age of 19, Reggie won the Premier League with Valletta F.C. in season 1989/90.

Throughout his days with Valletta Reggie won several major honours, including two clean sweeps of all honours with Valletta, i.e. the five cups (League, Trophy, Lowenbrau, Super 5 and Super Cup) in season 1996/1997 and the six cups in season 2000/2001 (League, Trophy, Centenary Cup, Lowenbrau, Super 5 and Super Cup).

In summer 2001, Reginald Cini joined Sliema Wanderers. He left the Blues and joined Marsaxlokk F.C. in season 2002/03. At the end of season 2003 Reggie ended his football career.